Grounded Evidence Chain: Drug Risk Reduction via NAL

Pipeline: PubMed OR → NAL frequency (f=OR/(1+OR)) → confidence (c=log10(N)/6) → revision

Drug	Effect	OR	N	PMID	f	c
metformin	cancer risk reduction	0.73	108,161	22182508	0.422	0.839
metformin	all-cause mortality	0.67	1,066,408	28802803	0.401	0.950
aspirin	colorectal cancer	0.71	14,033	31722088	0.415	0.691
statin	alzheimer risk	0.72	3,994,117	30735554	0.419	0.950

Revision: Metformin cross-claim similarity (0.259, 0.315) — low because cancer risk and mortality are different effects. Higher N → higher confidence.